Author

Keith R. Griffith

Pennsylvania State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 9

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Organism:mouse· 9 Approach:experimental assay· 8 Assay:electronic health records· 5 Research Focus:cell type annotation· 4 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Nicole A. CrowleyiD· 9 shared Avery R. SicheriD· 6 shared Dakota F. BrockwayiD· 6 shared Grace C. SmithiD· 4 shared Md Shakhawat HossainiD· 4 shared Patrick J. DrewiD· 4 shared Laurel R. SeemilleriD· 3 shared Nigel C. Dao· 3 shared

Activity by Year

2022-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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9 shared papersNeuroscience

Nicole A. CrowleyORCID

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9 papers

Recent·Most cited

Prolonged developmental programming of somatostatin neurons defines adolescent remodeling of the prelimbic, but not barrel, cortex

Avery R. Sicher, Lauren N. Beloate, Varya Zlotnik, Keith R. Griffith, Erin Wolfanger, Hayreddin Said Ünsal, Nanyin Zhang, Nicole A. Crowley

The paper compares the developmental maturation of somatostatin-expressing interneurons in the prelimbic and barrel cortices, finding prolonged remodeling in the prelimbic cortex.

bioRxiv · Jul 28, 2026 · PreprintNeuroscience

Type-I nNOS neurons orchestrate cortical neural activity and vasomotion

Kevin Turner, Dakota F. Brockway, Md Shakhawat Hossain, Keith R. Griffith, Denver I. Greenawalt, Qingguang Zhang, Kyle W. Gheres, Nicole A. Crowley, Patrick J. Drew

This study shows that type-I nNOS neurons regulate neural and vascular dynamics in the brain by altering activity patterns and blood volume responses.

eLife · Nov 11, 2025Peer-reviewedNeuroscience

Alcohol consumption drives sex- and region- specific disruption of somatostatin signaling in mice

Dakota F. Brockway, Keith R. Griffith, Andrew J. Kacala, Lauren Bellfy, Laurel R. Seemiller, Matthew Ulrich, Joseph M. Ricotta, Md Shakhawat Hossain, Janine L. Kwapis, Patrick J. Drew, Nicole A. Crowley

This study shows alcohol consumption disrupts somatostatin signaling in the prelimbic prefrontal cortex of mice, with potential implications for alcohol use disorder treatment.

bioRxiv · Jun 16, 2025 · PreprintNeuroscience

Adolescent alcohol consumption differentially alters sexually-divergent behaviors and infralimbic cortex function in mice

Laurel R. Seemiller, Hayreddin Said Ünsal, Yiyan Xie, Md Shakhawat Hossain, Avery R. Sicher, Keith R. Griffith, Kaleah Tuttle, Bryce Johnson-Dendy, Emily McDonald, Lauren N. Beloate, Patrick J. Drew, Nanyin Zhang, Nicole A. Crowley

This study shows adolescent alcohol exposure in mice leads to sex-specific behavioral and neural changes, with females showing increased alcohol preference and males showing altered cellular excitability.

bioRxiv · Jun 5, 2025 · PreprintNeuroscience

Voluntary adolescent alcohol exposure does not robustly increase adulthood consumption of alcohol in multiple mouse and rat models

Avery R. Sicher, Andrea Liss, Valentina Vozella, Paige Marsland, Laurel R. Seemiller, Matthew Springer, William D. Starnes, Keith R. Griffith, Grace C. Smith, Amy Astefanous, Terrence Deak B, Marisa Roberto, Florence P. Varodayan, Nicole A. Crowley

This paper shows that adolescent voluntary alcohol exposure in mice and rats does not reliably increase adult alcohol consumption across multiple models and labs.

Addiction Neuroscience · Aug 3, 2024Peer-reviewedNeuroscience

MODERATE ALCOHOL CONSUMPTION INDUCES LASTING IMPACTS ON PREFRONTAL CORTICAL SIGNALING IN MICE

Grace C. Smith, Keith R. Griffith, Avery R. Sicher, Dakota F. Brockway, Elizabeth A. Proctor, Nicole A. Crowley

This study shows that moderate alcohol consumption in mice affects prefrontal cortical signaling and neuronal excitability, potentially influencing Alzheimer's disease progression.

bioRxiv · Apr 3, 2024 · PreprintNeuroscience

Somatostatin peptide signaling dampens cortical circuits and promotes exploratory behavior

Dakota F. Brockway, Keith R. Griffith, Chloe M. Aloimonos, Thomas T. Clarity, J. Brody Moyer, Grace C. Smith, Nigel C. Dao, Md Shakhawat Hossain, Patrick J. Drew, Joshua A. Gordon, David A. Kupferschmidt, Nicole A. Crowley

This study investigates the role of somatostatin peptide signaling in the prelimbic cortex, showing it dampens cortical circuits and promotes exploratory behavior through specific physiological and pharmacological mechanisms.

Cell Reports · Aug 1, 2023Peer-reviewedNeuroscience

Adolescent binge drinking leads to long lasting changes in cortical microcircuits in mice

Avery R. Sicher, William D. Starnes, Keith R. Griffith, Nigel C. Dao, Grace C. Smith, Dakota F. Brockway, Nicole A. Crowley

This study shows that adolescent binge drinking in mice causes lasting changes in cortical microcircuit function, specifically affecting SST neuron excitability and pyramidal neuron activity.

Neuropharmacology · May 1, 2023Peer-reviewedNeuroscience

Somatostatin Neurons in the Bed Nucleus of the Stria Terminalis Play a Sex-Dependent Role in Binge Drinking

Malini Suresh Nair, Nigel C. Dao, Daniela Lopez Melean, Keith R. Griffith, William D. Starnes, J. Brody Moyer, Avery R. Sicher, Dakota F. Brockway, Kathleen D. Meeks, Nicole A. Crowley

This study investigates the role of somatostatin neurons in the bed nucleus of the stria terminalis in binge drinking, finding sex-dependent effects in female mice.

bioRxiv · Feb 23, 2022 · PreprintNeuroscience