Tharun Selvam Mahendran

This study shows that electrostatic interactions between intrinsically disordered regions drive G3BP1 condensate ageing, with RNA modulating these interactions and delaying dynamic arrest.

This study shows multi-component biomolecular condensates suppress amyloid formation by sequestering proteins, limiting their availability for fibril formation.

This paper introduces a synthetic intrinsically disordered protein coating that enhances oral delivery of peptide drugs by protecting them from gastric acid and enabling targeted intestinal release.

This study shows that L-arginine prevents Tau condensates from turning into amyloid fibrils without affecting phase separation, preserving their function.

This study shows that repeat RNAs form nanoscale clusters within biomolecular condensates, driven by sequence features and RNA secondary structure, and that G3BP1 buffers these interactions.

The paper shows that separable interactions in A1-LCD allow tunable metastability of condensates, which can suppress amyloid fibril formation even with ALS mutations.