Theresa Kagermeier

Organotchi: an open-source tool for the automated segmentation, morphological characterization, and longitudinal tracking of organoids

Organotchi automates segmentation and morphological analysis of neural organoids, quantifying features and tracking changes over time to improve quality assessment and downstream analysis.

Multiomics analysis identifies VPA-induced changes in neural progenitor cells, ventricular-like regions, and cellular microenvironment in dorsal forebrain organoids

This study examines VPA-induced changes in dorsal forebrain organoids using multiomics approaches, revealing disruptions in ECM and microenvironment signaling.

Comparing the impact of sample multiplexing approaches for single-cell RNA-sequencing on downstream analysis using cerebellar organoids

This study compares two single-cell RNA-sequencing multiplexing techniques, 10x and Parse, on cerebellar organoids, finding similar cellular diversity but differences in transcript capture and cell stress.

Human organoid model of PCH2a recapitulates brain region-specific pathology

This study develops human organoid models of PCH2a to investigate brain region-specific pathology, finding size reductions in cerebellar organoids and altered proliferation kinetics.

Human brain organoid model of maternal immune activation identifies radial glia cells as selectively vulnerable

This study uses a human 3D organoid model to show that maternal immune activation increases radial glia cell vulnerability and identifies species-specific gene responses linked to ASD risk.