Simone Mayer

Organotchi automates segmentation and morphological analysis of neural organoids, quantifying features and tracking changes over time to improve quality assessment and downstream analysis.

This study identifies candidate regulatory mechanisms for cerebellar vulnerability in PCH by analyzing variant effects and gene expression patterns.

This study examines VPA-induced changes in dorsal forebrain organoids using multiomics approaches, revealing disruptions in ECM and microenvironment signaling.

This study compares two single-cell RNA-sequencing multiplexing techniques, 10x and Parse, on cerebellar organoids, finding similar cellular diversity but differences in transcript capture and cell stress.

This study develops human organoid models of PCH2a to investigate brain region-specific pathology, finding size reductions in cerebellar organoids and altered proliferation kinetics.

The paper constructs a single-cell transcriptomic atlas of human cortical development, identifying lineage and sex-specific gene expression programs linked to autism risk.

This study uses a human 3D organoid model to show that maternal immune activation increases radial glia cell vulnerability and identifies species-specific gene responses linked to ASD risk.

The paper identifies molecular subtypes of human interneuron progenitors and immature interneurons using single-cell RNA sequencing and compares them to mouse data, revealing species-specific gene programs.