This study identifies transcriptional states and regulators of spermatogonial stem cell differentiation in marmoset testes across developmental stages.

bioRxiv · Apr 6, 2026 · PreprintDevelopmental Biology

Optical tissue clearing and 3D imaging of intact primate testicular tissue: a novel technology development

Pauline Wanjiku Kibui, Sarah Weischer, Nicola von Ostau, Jochen Heß, Nils Kirschnick, Thomas Zobel, Stefan Schlatt

This paper introduces PT-CLEAR3D, a method for 3D imaging of intact primate testicular tissue, revealing cellular and structural details across three species.

PLoS ONE · Dec 8, 2025Peer-reviewedDevelopmental Biology

Genome-wide DNA methylation changes in human spermatogenesis

Lara Marie Siebert-Kuss, Verena Dietrich, Sara Di Persio, Jahnavi Bhaskaran, Martin Stehling, Jann‐Frederik Cremers, Sarah Sandmann, Julian Varghese, Sabine Kliesch, Stefan Schlatt, Juan M. Vaquerizas, Nina Neuhaus, Sandra Laurentino

This study identifies genome-wide DNA methylation changes during human spermatogenesis and their disruption in disturbed spermatogenesis, highlighting hypomethylation at specific regions and transposable elements.

The American Journal of Human Genetics · May 16, 2024Peer-reviewedGenetics

Stage-specific gene and transcript dynamics in human male germ cells

Lara Marie Siebert-Kuss, Henrike Krenz, Tobias Tekath, Marius Wöste, Sara Di Persio, Nicole Terwort, Margot Julia Wyrwoll, Jann‐Frederik Cremers, Joachim Wistuba, Martin Dugas, Sabine Kliesch, Stefan Schlatt, Frank Tüttelmann, Jörg Gromoll, Nina Neuhaus, Sandra Laurentino

The paper analyzes transcriptomes of human testis with different germ cell arrest stages to identify gene and transcript dynamics during spermatogenesis.

Life Science Alliance · Nov 29, 2022Peer-reviewedMolecular Biology

EGR4-dependent decrease of UTF1 is associated with failure to reserve spermatogonial stem cells in infertile men

Sara Di Persio, Tobias Tekath, Lara Marie Siebert-Kuss, Jann‐Frederik Cremers, Joachim Wistuba, Xiaolin Li, Gerd Meyer zu Hörste, Hannes C. A. Drexler, Margot Julia Wyrwoll, Frank Tüttelmann, Martin Dugas, Sabine Kliesch, Stefan Schlatt, Sandra Laurentino, Nina Neuhaus

The paper identifies EGR4-dependent UTF1 downregulation as a factor in reduced reserve spermatogonial stem cells in infertile men, linked to altered chromatin structure.

Cell Reports Medicine · Sep 1, 2021Peer-reviewedMolecular Biology