Hannes C. A. Drexler

The small ORF (smORF)-encoded polypeptide MIRINE promotes neuronal differentiation in vertebrate brain development

The paper identifies MIRINE, a small ORF-encoded polypeptide that promotes neuronal differentiation in vertebrate brain development by regulating the balance between proliferation and maturation.

Fertilization offsets the maternal age effect on mouse oocytes provided the oviduct is not itself aged

This study shows that fertilization can reverse the negative effects of maternal age on oocyte quality in mice, provided the fertilization environment is not aged.

A novel and critical role of the intracellular Zona Pellucida protein 2 (ZP2) for blastocyst formation in mice

This study shows that ZP2, a zona pellucida protein, is re-synthesized and functionally required in mouse embryos, playing an active role in blastocyst formation and cell lineage development.

tRNA modifications tune decoding of codon pairs to prevent cellular quality control responses

This study shows that tRNA modifications affect codon pair decoding, leading to ribosome stalling and triggering quality control responses to prevent protein aggregation.

Sphingolipid metabolism orchestrates the establishment of the adult hair follicle stem cell niche to control skin homeostasis

This study identifies CerS4's role in regulating hair follicle stem cell niche formation through sphingolipid metabolism, impacting skin homeostasis and barrier function.

Intracellular fraction of zona pellucida protein 3 is required for the oocyte to embryo transition in mice

This study identifies a novel intracellular function of zona pellucida proteins in mice, showing they are critical for embryonic cell survival during the oocyte-to-embryo transition.

EGR4-dependent decrease of UTF1 is associated with failure to reserve spermatogonial stem cells in infertile men

The paper identifies EGR4-dependent UTF1 downregulation as a factor in reduced reserve spermatogonial stem cells in infertile men, linked to altered chromatin structure.

An integrated genome-wide multi-omics analysis of gene expression dynamics in the preimplantation mouse embryo

The paper integrates multi-omics data to analyze gene expression dynamics in mouse embryos, revealing discrepancies between transcript and protein levels during early development.