Author

Seongsik Yun

Northwestern UniversityORCID 0000-0002-2909-1482Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:spatial domain detection· 1 Organism:zebrafish· 1

Frequent Co-Authors

Jones G. ParkeriD· 3 shared Anis ContractoriD· 2 shared Madison M. MartiniD· 2 shared Nai-Hsing YehiD· 2 shared Stefan W. Fleps· 2 shared Ann KennedyiD· 1 shared Anu Shahapal· 1 shared Arin PamukcuiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersNeuroscience

Jones G. ParkerORCID

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4 papers

Recent·Most cited

Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output

John J Marshall, Jian Xu, Nai-Hsing Yeh, Seongsik Yun, Toshihiro Nomura, John N. Armstrong, Jones G. Parker, Anis Contractor

This study shows that mGluR5 modulates co-activity of striatal direct pathway neurons and motor output through synaptic plasticity.

eLife · Jan 27, 2026Peer-reviewedNeuroscience

Modulating D1 rather than D2 receptor-expressing spiny-projection neurons corresponds to optimal antipsychotic effect

Seongsik Yun, Ben Yang, Justin D. Anair, Madison M. Martin, Stefan W. Fleps, Arin Pamukcu, Nai-Hsing Yeh, Anis Contractor, Ann Kennedy, Jones G. Parker

The paper investigates the neural mechanisms of antipsychotic drugs by comparing their effects on D1- and D2-receptor-expressing spiny-projection neurons in mice, finding that modulating D1-SPNs correlates with therapeutic efficacy.

Nature Neuroscience · Jul 13, 2023Peer-reviewedNeuroscience

Selective Nigrostriatal Dopamine Excess Impairs Behaviors Linked to the Cognitive and Negative Symptoms of Psychosis

Nicolette A. Moya, Seongsik Yun, Stefan W. Fleps, Madison M. Martin, Jacob A. Nadel, Lisa R. Beutler, Larry S. Zweifel, Jones G. Parker

This study shows that selectively increasing dopamine in the dorsal striatum impairs behaviors linked to negative and cognitive symptoms of psychosis, challenging the idea that excess dopamine is not involved in these symptoms.

Neuropsychopharmacology · Nov 15, 2022Peer-reviewedNeuroscience

FAM19A5l affects mustard oil-induced peripheral nociception in zebrafish

Inyoung Jeong, Seongsik Yun, Anu Shahapal, Eun Bee Cho, Sun Wook Hwang, Jae Young Seong, Hae-Chul Park

This study identifies FAM19A5l in zebrafish as a regulator of mustard oil-induced nociception by modulating TRPA1b and NGFa expression.

Molecular Neurobiology · Jun 26, 2021Peer-reviewedNeuroscience