Nicholas J. H. Salisbury

E2F1-3 activate Merkel cell polyomavirus early transcription and viral replication

This study identifies E2F1-3 as activators of MCPyV early transcription and replication through binding to the NCCR, revealing an E2F/LT/RB1 feedback loop that supports viral replication.

Delta-catenin is required for cell proliferation in virus positive Merkel cell carcinoma cell lines but not in human fibroblasts

The paper identifies delta-catenin as essential for proliferation in virus-positive Merkel cell carcinoma cells but not in fibroblasts, revealing distinct roles in viral infection and tumorigenesis.

Polyomavirus ALTOs, but not MTs, downregulate viral early gene expression by activating the NF-κB pathway

This study shows that polyomavirus ALTOs, but not MTs, downregulate viral early gene expression by activating the NF-κB pathway, acting as tumor suppressors in Merkel cell carcinoma.

Merkel cell polyomavirus protein ALTO modulates TBK1 activity to support persistent infection

This study identifies MCPyV protein ALTO as a factor that modulates the STING-TBK1 pathway to limit viral replication and maintain persistent infection.