Long-access heroin self-administration induces region specific reduction of grey matter volume and microglia reactivity in the rat.
Nazzareno Cannella, Stefano Tambalo, Veronica Lunerti, Giulia Scuppa, Luisa de Vivo, Sarah Abdulmalek, Analia Kinen, James Mackle, Brittany N. Kuhn, Leah C. Solberg Woods, Dongjun Chung, Peter W. Kalivas, Laura Soverchia, Massimo Ubaldi, Gary Hardiman, , Roberto Ciccocioppo
This study shows that long-access heroin self-administration in rats reduces grey matter volume in specific brain regions and alters microglia morphology, suggesting a link between neuroinflammation and structural brain changes.
Brain Behavior and Immunity · Mar 5, 2024Peer-reviewedNeuroscience