KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival
Thomas L. Ekstrom, Zhangshuai Dai, Julia Thiel, Akshay Kanakan, Bishakha Joyeeta Saha, Meghana Manjunath, Nadine Schacherer, Pavlos Bousounis, Emily L. Siegler, Amro M. Abdelrahman, Yara Souto, Frank Eßmann, Zeynab Najafova, Sven Beyes, Mark Joseph Truty, , Steven A. Johnsen
This study identifies KLF5-bound enhancers in pancreatic cancer that regulate cell survival, showing their subtype-independent role in maintaining tumor viability.
Science Advances · Mar 18, 2026Peer-reviewedCancer Biology