Scott R. Tyler

Anti-correlated Feature Selection Prevents False Discovery of Subpopulations in scRNAseq

The paper identifies anti-correlated gene selection as a method to prevent false discovery of subpopulations in scRNA-seq by reducing erroneous subdivisions in clustering.

Acetate supplementation rescues social deficits and alters transcriptional regulation in prefrontal cortex of Shank3 deficient mice

The paper shows acetate supplementation improves social deficits and changes gene expression in the prefrontal cortex of Shank3-deficient mice.

Self-supervised Benchmarking for scRNAseq Clustering

This paper benchmarks scRNAseq clustering pipelines using a self-supervised approach, identifying a novel metabolic gene signature linked to hepatocellular carcinoma survival.

Erasure of Biologically Meaningful Signal by Unsupervised scRNAseq Batch-correction Methods

This paper shows that common scRNA-seq batch correction methods erase biological variation, and proposes new measures to assess batch effects and their impact on cluster composition and topologies.

A Molecular network approach reveals shared cellular and molecular signatures between chronic fatigue syndrome and other fatiguing illnesses

This study identifies shared molecular signatures between chronic fatigue syndrome and other fatiguing illnesses using RNA-sequencing data from blood samples.