Elodie Drapeau

Distinct genetic liability profiles define clinically relevant patient strata across common diseases

The paper identifies genetically distinct patient subgroups across diseases by analyzing polygenic risk and pathway convergence.

Acetate supplementation rescues social deficits and alters transcriptional regulation in prefrontal cortex of Shank3 deficient mice

The paper shows acetate supplementation improves social deficits and changes gene expression in the prefrontal cortex of Shank3-deficient mice.

Schizophrenia-associated somatic copy number variants from 12,834 cases reveal contribution to risk and recurrent, isoform-specific NRXN1 disruptions

This study identifies somatic copy number variants (sCNVs) in schizophrenia cases, revealing their contribution to risk and specific NRXN1 disruptions.

Using brain cell-type-specific protein interactomes to interpret genetic data in schizophrenia

The paper uses brain cell-type-specific protein interactomes to interpret genetic data in schizophrenia and identifies enriched networks and genes associated with the disease.

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

This study identifies sex-dependent genetic risk loci shared and specific to mood and psychotic disorders using genome-wide interaction analysis.

Developmental and behavioral phenotypes in a new mouse model of DDX3X syndrome

This study develops a Ddx3x haploinsufficient mouse model to investigate DDX3X syndrome, finding developmental and behavioral abnormalities linked to brain structural changes.

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

The paper compares ten polygenic score methods for psychiatric disorders across multiple cohorts, finding that some methods significantly improve prediction statistics over the baseline PC+T method.

Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan McDermid syndrome and autism

The paper uses hiPSC-derived neural cells from PMS patients and siblings to identify transcriptional changes, finding altered Wnt signaling and shared ASD-related genes.

Age at first birth in women is genetically associated with increased risk of schizophrenia

The paper finds a genetic association between schizophrenia risk and age at first birth in women, with different genetic correlations in younger and older age groups.

Estimation of genetic correlation using linkage disequilibrium score regression and genomic restricted maximum likelihood

This study compares LDSC and GREML methods for estimating genetic correlation, showing GREML provides higher accuracy, especially in the presence of genetic heterogeneity.