Anna K. Marciniak-Czochra

The paper develops a stochastic framework to infer regulatory mechanisms from population-level variability in neural stem cell dynamics, showing that variance patterns reveal distinct regulatory processes.

The paper introduces a mathematical model of Wnt-Dickkopf interactions in Hydra to explain body-axis formation through mutual inhibition, showing it can drive pattern formation across a broad parameter range.

This study uses mathematical models to analyze regulatory feedback mechanisms in adult neurogenesis, finding that neural stem cells predominantly regulate lineage dynamics.

This study identifies a mechanochemical feedback loop between Wnt signaling and tissue stretching that drives axis formation in Hydra regeneration.

The paper investigates WUSCHEL protein mobility in Arabidopsis thaliana shoot apical meristem, showing it is balanced between transport and retention, independent of CLAVATA3.

This study uses genetic interference to investigate HvNotch's role in Hydra development, revealing its impact on regeneration, patterning, and boundary formation.

This study shows interferon regulates stem cell function across all ages by controlling mTOR and cell cycle, with beneficial effects in youth and harmful effects in aging brains.

The paper develops a mathematical model to estimate stem cell numbers and identify functional heterogeneities in fish gill growth using a Markov model and stochastic simulations.

This paper uses a Cellular Potts Model to simulate cell movement and aggregation during kidney development, showing that chemoattractant secretion and cell adhesion differences drive NP cell patterning.

The paper challenges the classical Turing pattern theory by proposing two alternative frameworks for pattern formation, emphasizing far-from-equilibrium dynamics and mechano-chemical feedback.

The paper identifies AAV variants that efficiently target adult neural stem cells in the subventricular zone, enabling genetic modification for potential regenerative therapies.

The paper shows that hippocampal stem cells in mice undergo progressive behavioral changes that reduce depletion and ensure lifelong neurogenesis.

This study shows that Hydra uses two separate patterning loops for body axis and head formation, challenging the previous single-loop model.

This study identifies HAS-7, an astacin proteinase, as a Wnt processing factor that regulates head formation in Hydra by controlling Wnt ligand activity and axis patterning.

The paper develops a mathematical model to study how hormonal signals influence cell fate transitions in plant shoot meristems, revealing the role of HECATE in stem cell differentiation.

The paper identifies distinct homeostatic and growth adult stem cell populations in medaka gills, showing their spatial separation and functional specialization.

This study uses a mathematical model and experimental data to show that aged hippocampal NSCs remain quiescent longer and have a higher reactivation probability, which can be rescued by increased Wnt activity.