PD-1 prelimits both the cytotoxic and exhaustion potential in thymic CD8+ T cells and impacts the maintenance of peripheral tumor immunity
Zhiming Mao, Jacob B. Hirdler, Joanina K. Gicobi, Mark Andrew Maynes, Michelle A. Hsu, Emilia Rae Dellacecca, Wenjing Zhang, Jacob J. Teske, Ying Li, Geoffrey Zhao, Fabrice Lucien, Henrique Borges da Silva, Daniel D. Billadeau, Haidong Dong
This study identifies PD-1's role in regulating effector potential and exhaustion in thymic CD8+ T cells, showing that PD-1 inhibition enhances expansion but leads to exhaustion in tumor tissues.
bioRxiv · Jan 18, 2025 · PreprintImmunology