Author

Daniel D. Billadeau

Mayo ClinicORCID 0000-0002-2296-9547Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Daniel D. Billadeau1 paper

Biology Disciplines

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Adrian T. TingiD· 1 shared Allison R. CarriD· 1 shared Emilia Rae DellaceccaiD· 1 shared Erica N. Krogman· 1 shared Fabrice LucieniD· 1 shared Geoffrey Zhao· 1 shared Haidong DongiD· 1 shared Henrique Borges da SilvaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

Adrian T. TingORCID

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2 papers

Recent·Most cited

T cells use TNF and IFNγ for paracrine killing with target discrimination programmed by pathogen-derived factors

Matthew C. Guttormson, Erica N. Krogman, Allison R. Carr, Skylar A. Rizzo, Josey Muske, Maia Ziaee, Nicholas R. Therrien, Nicholas D. Sun, Romina Ghale, Michael J. Medlyn, Daniel D. Billadeau, Larry R. Pease, Kathryn A. Knoop, Adrian T. Ting

The paper shows T cells can kill target cells via TNF and IFNγ in a paracrine, perforin-independent manner, with pathogen-derived factors enabling selective elimination of infected cells.

bioRxiv · Dec 25, 2025 · PreprintImmunology

PD-1 prelimits both the cytotoxic and exhaustion potential in thymic CD8+ T cells and impacts the maintenance of peripheral tumor immunity

Zhiming Mao, Jacob B. Hirdler, Joanina K. Gicobi, Mark Andrew Maynes, Michelle A. Hsu, Emilia Rae Dellacecca, Wenjing Zhang, Jacob J. Teske, Ying Li, Geoffrey Zhao, Fabrice Lucien, Henrique Borges da Silva, Daniel D. Billadeau, Haidong Dong

This study identifies PD-1's role in regulating effector potential and exhaustion in thymic CD8+ T cells, showing that PD-1 inhibition enhances expansion but leads to exhaustion in tumor tissues.

bioRxiv · Jan 18, 2025 · PreprintImmunology