Yoke Chin Chai

This paper introduces human myelin spheres (MyS) as a model for studying myelination and demyelination, showing their ability to form myelinated neurons and mimic in vivo oligodendrocyte development.

MyeliMAP models human CNS myelination using hPSC-derived neurons and oligodendrocytes in a microfluidic platform, showing enhanced action potential conduction and stabilized network activity.

This study investigates the role of oligodendroglia in Wolfram syndrome using mouse models and iPSC-derived cells, finding preserved oligodendroglia function and suggesting alternative targets for treatment.