Walter Patrick Devine

This paper describes the implementation of preemptive pharmacogenomics testing linked to an electronic clinical decision support system at UCSF Health to guide medication decisions.

The paper introduces MAGIC, a cloning system enabling modular assembly of gene constructs for use in vertebrate models.

The paper uses snRNA-seq to analyze mosaic chromosome 1q gain in a case of epilepsy with hyaline protoplasmic astrocytopathy, finding cell-type-specific gene expression changes in neurons and astrocytes.

The study finds no association between diagnostic yield of exome sequencing and genetic ancestry in a diverse pediatric and prenatal cohort.

The paper identifies a Mesp1-dependent developmental breakpoint in cardiac precursor cell specification using single-cell transcriptomics and chromatin accessibility analysis in mouse embryos.

The paper models TBX5 haploinsufficiency in iPSC-derived cardiomyocytes to identify gene regulatory network imbalances linked to congenital heart disease.

The paper develops a novel Dll4 reporter allele to accurately monitor Dll4 expression in embryonic and adult mice, overcoming limitations of previous reporter lines.