Masafumi Horie

HPV-Associated Tonsillar Intraepithelial Neoplasia and Oral High-Risk HPV mRNA as a Candidate Biomarker

The paper identifies HPV-associated premalignant lesions in tonsils and suggests oral HR-HPV mRNA as a potential biomarker for early detection.

Highly plastic macrophage niches orchestrate acquired quiescence and reactivation in breast-cancer bone metastasis

The paper identifies CXCL16 macrophages in bone metastases that transiently restrain cancer growth and G-CSF niches that promote reactivation, revealing CAF-bone-marrow interactions as a therapeutic target.

Loss of tight junction protein claudin 18 uncovers alveolar epithelial stem cell plasticity and emergence of non-fibrogenic transitional progenitors

The paper identifies regeneration-associated transitional progenitors (RATPs) in Cldn18 knockout mice, showing they are less fibrogenic and contribute to lung repair rather than fibrosis.

Pathological Angiogenesis Precedes the Onset of Aortic Dissection

This study identifies pathological angiogenesis as a key driver of non-heritable aortic dissection, revealing its role in disease onset and potential therapeutic targets.

TCR clonality and TCR clonal expansion in the in situ microenvironment of non-small cell lung cancer

This study links TCR clonality in NSCLC to genetic mutations, immune phenotypes, immunotherapy response, and patient survival.