Timothy R. Blosser

Whole-transcriptome-scale and isoform-resolved spatial imaging of single cells in complex tissues

The paper introduces a spatial transcriptomics method for whole-transcriptome and isoform-resolved analysis of single cells in mouse brain tissue, revealing spatial diversity and cell-type-specific isoform usage.

Inference of single cell profiles from histology stains with the Single-Cell omics from Histology Analysis Framework (SCHAF)

SCHAF generates spatially resolved single-cell transcriptomes from H&E histology images using vision transformers and adversarial learning, showing good agreement with ground-truth data.

Mapping the cellular and molecular organization of mouse cerebral aging by single-cell transcriptome imaging

This study maps age-related changes in mouse brain cellular and molecular organization using spatial transcriptomics, revealing significant shifts in non-neuronal cells and glial activation patterns.

Decoding molecular and cellular heterogeneity of nucleus accumbens with high-throughput scRNA-seq and MERFISH

This study uses scRNA-seq and MERFISH to reveal the molecular and spatial heterogeneity of mouse nucleus accumbens cells and their functional implications.