Renchao Chen

MERFISH 2.0, an ultra-sensitive single-cell spatial transcriptomics imaging chemistry across diverse tissue types

MERFISH 2.0 improves transcript detection sensitivity in degraded and archival tissues, enhancing spatial transcriptomic analysis of human and mouse samples.

A molecularly defined NAcSh D1 subtype controls feeding and energy homeostasis

The paper identifies a specific NAcSh D1 subtype that regulates feeding and energy homeostasis through molecular and circuit-level mechanisms.

Accurate inference of genome-wide spatial expression with iSpatial

iSpatial integrates spatial transcriptomic and scRNA-seq data to infer genome-wide spatial gene expression patterns with higher accuracy and reduced false signals.

Decoding molecular and cellular heterogeneity of nucleus accumbens with high-throughput scRNA-seq and MERFISH

This study uses scRNA-seq and MERFISH to reveal the molecular and spatial heterogeneity of mouse nucleus accumbens cells and their functional implications.