Author

Megan M. Senchuk

Van Andel InstituteORCID 0000-0002-7744-2021Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Jeremy M. Van RaamsdonkiD· 4 shared Sonja K. Soo· 3 shared Annika TraaiD· 2 shared Ulrich AnglasiD· 2 shared Aura A Tamez González· 1 shared Darren J. MooreiD· 1 shared Emily Machiela· 1 shared Grant F Booth· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersGenetics

Jeremy M. Van RaamsdonkORCID

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4 papers

Recent·Most cited

GeneticsbioRxivPreprintJul 21, 2026

Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging Strategies

Zenith D. Rudich, Jiaxi Guan, Aura A Tamez González…·Jeremy M. Van Raamsdonk

This study identifies 196 upregulated and 62 downregulated aging genes across long-lived C. elegans mutants, revealing distinct gene expression strategies for longevity.

1 citation

C. elegansbulk RNA-seq

GeneticsFree Radical Biology and MedicinePeer-reviewedJan 17, 2025

Mitochondrial superoxide acts in the intestine to extend longevity

Thomas Liontis, Megan M. Senchuk, Shusen Zhu…·Jeremy M. Van Raamsdonk

This study shows that reducing mitochondrial superoxide in the intestine extends longevity in worms by improving stress resistance.

4 citations

experimental assay

NeurosciencebioRxivPreprintOct 19, 2021

Identification of novel therapeutic targets for polyglutamine toxicity disorders that target mitochondrial fragmentation

Annika Traa, Emily Machiela, Paige D. Rudich…·Jeremy M. Van Raamsdonk

This study identifies novel genetic targets that reduce mitochondrial fragmentation in a C. elegans model of polyglutamine toxicity, improving movement and lifespan.

6 citations

C. elegansexperimental assay

NeuroscienceNeurobiology of DiseasePeer-reviewedJan 13, 2021

Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson's disease

Megan M. Senchuk, Jeremy M. Van Raamsdonk, Darren J. Moore

The paper investigates how lifespan-extending genetic pathways provide neuroprotection in a nematode model of Parkinson's disease, showing dissociation between lifespan extension and neuroprotection.

15 citations

C. elegansstatistical model