Author

Sonja K. Soo

Research Institute of the McGill University Health Centre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Genetics· 4 Neuroscience· 1

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Organism:C. elegans· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jeremy M. Van RaamsdonkiD· 5 shared Annika TraaiD· 4 shared Meeta MistryiD· 3 shared Megan M. SenchukiD· 3 shared Ulrich AnglasiD· 2 shared Zenith D. Rudich· 2 shared Alibek MoldakozhayeviD· 1 shared Aura A Tamez González· 1 shared

Activity by Year

2021-2026 · peak 2/yr

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10 top collaborators · 33 mutual co-author links

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5 shared papersGenetics

Jeremy M. Van RaamsdonkORCID

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5 papers

Recent·Most cited

Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging Strategies

Zenith D. Rudich, Jiaxi Guan, Aura A Tamez González, Grant F Booth, Sonja K. Soo, Ulrich Anglas, Meeta Mistry, Megan M. Senchuk, Jeremy M. Van Raamsdonk

This study identifies 196 upregulated and 62 downregulated aging genes across long-lived C. elegans mutants, revealing distinct gene expression strategies for longevity.

bioRxiv · Jul 21, 2026 · PreprintGenetics

Mitochondrial superoxide acts in the intestine to extend longevity

Thomas Liontis, Megan M. Senchuk, Shusen Zhu, Suleima Jacob‐Tomas, Ulrich Anglas, Annika Traa, Sonja K. Soo, Jeremy M. Van Raamsdonk

This study shows that reducing mitochondrial superoxide in the intestine extends longevity in worms by improving stress resistance.

Free Radical Biology and Medicine · Jan 17, 2025Peer-reviewedGenetics

Genetic basis of enhanced stress resistance in long-lived mutants highlights key role of innate immunity in determining longevity

Sonja K. Soo, Annika Traa, Zenith D. Rudich, Alibek Moldakozhayev, Meeta Mistry, Jeremy M. Van Raamsdonk

The paper examines nine long-lived C. elegans mutants to show a strong correlation between stress resistance and longevity, driven by overlapping genetic pathways.

Aging Cell · Dec 13, 2022Peer-reviewedGenetics

Identification of novel therapeutic targets for polyglutamine toxicity disorders that target mitochondrial fragmentation

Annika Traa, Emily Machiela, Paige D. Rudich, Sonja K. Soo, Megan M. Senchuk, Jeremy M. Van Raamsdonk

This study identifies novel genetic targets that reduce mitochondrial fragmentation in a C. elegans model of polyglutamine toxicity, improving movement and lifespan.

bioRxiv · Oct 19, 2021 · PreprintNeuroscience

Mitochondrial unfolded protein response transcription factor ATFS-1 increases resistance to exogenous stressors through upregulation of multiple stress response pathways

Sonja K. Soo, Annika Traa, Meeta Mistry, Jeremy M. Van Raamsdonk

This study shows that ATFS-1 activates multiple stress response pathways to increase resistance to exogenous stressors but reduces lifespan when chronically active.

bioRxiv · Apr 26, 2021 · PreprintGenetics