Shusen Zhu

Elevated mitochondrial superoxide promotes longevity through a mitochondria-to-nucleus kinase signaling pathway

This study identifies a mitochondria-to-nucleus kinase signaling pathway that promotes longevity in sod-2 mutants by upregulating innate immunity and cuticle formation genes.

Mild activation of the mitochondrial unfolded protein response increases lifespan without increasing resistance to stress

This study shows that mild activation of the mitochondrial unfolded protein response (mitoUPR) through ATFS-1 can increase lifespan without enhancing stress resistance in worms.

Mitochondrial superoxide acts in the intestine to extend longevity

This study shows that reducing mitochondrial superoxide in the intestine extends longevity in worms by improving stress resistance.

Overexpression of mitochondrial fusion genes enhances resilience and extends longevity

This study shows that overexpressing mitochondrial fission or fusion genes increases lifespan and stress resistance in C. elegans, despite causing mitochondrial fragmentation.

Chronic cortisol exposure in early development leads to neuroendocrine dysregulation in adulthood

The paper investigates the long-term effects of chronic cortisol exposure during zebrafish embryonic development, finding persistent neuroendocrine dysregulation and altered gene expression in adulthood.

Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity

The paper identifies Klf9 as a key regulator of the transcriptomic response to glucocorticoid receptor activity in zebrafish larvae, showing it mediates proinflammatory gene upregulation under chronic cortisol exposure.