Author

Paige D. Rudich

Children's Hospital of PittsburghORCID 0000-0001-6979-9701Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein sequence· 1

Frequent Co-Authors

Todd LamitinaiD· 2 shared Annika TraaiD· 1 shared Carley Snoznik· 1 shared Emily Machiela· 1 shared James OosteniD· 1 shared Jelena Mojsilovic‐PetroviciD· 1 shared Jeremy M. Van RaamsdonkiD· 1 shared Megan M. SenchukiD· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

Todd LamitinaORCID

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3 papers

Recent·Most cited

Identification of novel therapeutic targets for polyglutamine toxicity disorders that target mitochondrial fragmentation

Annika Traa, Emily Machiela, Paige D. Rudich, Sonja K. Soo, Megan M. Senchuk, Jeremy M. Van Raamsdonk

This study identifies novel genetic targets that reduce mitochondrial fragmentation in a C. elegans model of polyglutamine toxicity, improving movement and lifespan.

bioRxiv · Oct 19, 2021 · PreprintNeuroscience

The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity

Carley Snoznik, Valentina Medvedeva, Jelena Mojsilovic‐Petrovic, Paige D. Rudich, James Oosten, Robert Gordon Kalb, Todd Lamitina

This paper identifies SPOP as a conserved regulator of C9orf72 dipeptide toxicity in C. elegans and mammalian neurons, showing SPOP inhibition protects against toxicity.

Proceedings of the National Academy of Sciences · Sep 30, 2021Peer-reviewedNeuroscience

PolyQ-independent toxicity associated with novel translational products from CAG repeat expansions

Paige D. Rudich, Simon C. Watkins, Todd Lamitina

This study evaluates the toxicity of CAG repeat-derived RAN polypeptides in C. elegans, finding that polyLeu is toxic independently of polyQ.

PLoS ONE · Apr 2, 2020Peer-reviewedNeuroscience