The paper shows neurons in the mouse brain receive nuclear and ribosomal material from oligodendrocytes, which persists into adulthood and occurs in specific brain regions.

bioRxiv · Nov 30, 2021 · PreprintNeuroscience

Reduction in CD11c+ microglia correlates with clinical progression in chronic experimental autoimmune demyelination

Florian Mayrhofer, Zhanna Dariychuk, Anthony Zhen, Daniel J. Daugherty, Peter G. C. Bannerman, Angela M. Hanson, David Pleasure, Athena M. Soulika, Wenbin Deng, Olga V. Chechneva

The paper shows that reduced CD11c+ microglia correlates with faster disease progression in a mouse model of multiple sclerosis.

Neurobiology of Disease · Nov 6, 2021Peer-reviewedNeuroscience

Role of PARP1 in oligodendrocyte differentiation during developmental myelination and remyelination after myelin damage

Yan Wang, Yanhong Zhang, Sheng Zhang, Bokyung Kim, Vanessa L. Hull, Jie Xu, Preeti Prabhu, Maria Gregory, Verónica Martínez‐Cerdeño, Xinhua Zhan, Wenbin Deng, Fuzheng Guo

This study identifies PARP1 as a key driver of oligodendrocyte differentiation and myelination, showing its role in both developmental and remyelination processes in the CNS.

Cell Reports · Oct 1, 2021Peer-reviewedNeuroscience

HIFα regulates developmental myelination independent of autocrine Wnt signaling

Sheng Zhang, Yan Wang, Jie Xu, Bokyung Kim, Wenbin Deng, Fuzheng Guo

This study shows HIFα regulates developmental myelination in the CNS independently of autocrine Wnt signaling, identifying a HIF-Sox9 pathway in OPC differentiation.

Journal of Neuroscience · Nov 18, 2020Peer-reviewedNeuroscience

Aberrant calcium signaling in astrocytes inhibits neuronal excitability in a human Down syndrome stem cell model

Grace Or Mizuno, Yinxue Wang, Guilai Shi, Yizhi Wang, Junqing Sun, Stelios Papadopoulos, Gerard Joey Broussard, Elizabeth K. Unger, Wenbin Deng, Jason Porter Weick, Anita Bhattacharyya, Chao-Yin Chen, Guoqiang Yu, Loren L. Looger, Lin Tian

Cell Reports · Jan 1, 2018Peer-reviewedNeuroscience