Scott L. Brincat

Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesia

The paper uses a mechanistic model to simulate propofol's effects on brain circuits, identifying a dose-dependent biomarker confirmed in empirical data.

Neural subspace reorganization reflects value-based decision making

The paper shows how value-based decisions reorganize neural subspaces in LPFC by rotating and expanding chosen option representations.

Disruption of interareal control during propofol anesthesia

This study uses control-theoretic methods to show that propofol anesthesia reduces interareal control in the brain, leading to a directional breakdown of cortical control.

BAYESIAN STATE-SPACE MODEL FOR JOINT INFERENCE OF OSCILLATORY DYNAMICS AND POINT-PROCESS COUPLING

This paper introduces a Bayesian state-space model to jointly infer oscillatory dynamics and spike-field coupling, showing improved frequency-specific estimates compared to classical methods.

Low-dimensional prefrontal representations of objects during working memory

The paper investigates the dimensionality of prefrontal cortex representations during working memory and finds they are low-dimensional, compressed compared to visual inputs.

Theta gates and routes information in the frontal cortex

This study investigates how theta oscillations coordinate neural activity in the frontal cortex of non-human primates during a dot pattern categorization task, revealing directional routing and cross-frequency interactions.

Similar destabilization of neural dynamics under different general anesthetics

The paper shows that different anesthetics destabilize neural dynamics similarly, affecting recovery and low-frequency power, and linking this to unconsciousness.

Emergent Traveling Waves in Neural Circuits

This study shows that traveling waves emerge in neural networks under biologically plausible constraints and support working memory, matching primate cortex recordings.

Oscillatory Control of Cortical Space as a Computational Dimension

The paper tests the Spatial Computing hypothesis by analyzing alpha/beta oscillations in non-human primates, finding they organize task-related information and constrain sensory expression in space.

Adaptive stretching of representations across brain regions and deep learning model layers

The paper shows that brain regions and deep learning models stretch representations along task-relevant dimensions to optimize performance through error minimization.

State-space trajectories and traveling waves following distraction

The paper shows that after distractions, neural activity in the prefrontal cortex returns to pre-disruption patterns through state-space rotations and traveling waves.

Working memory readout varies with frontal theta rhythms

The paper shows that working memory readout in the frontal eye field varies with theta rhythm phases, linked to performance in a visual memory task.

Recycling of prefrontal subspaces dynamically multiplexes information

The paper shows that prefrontal cortex subspaces are reused across time and for different information types, challenging previous assumptions about their fixed roles.

Convergent effects of different anesthetics on changes in phase alignment of cortical oscillations

This study shows that ketamine and dexmedetomidine induce similar cortical phase alignment patterns in nonhuman primates, suggesting a common mechanism for loss of responsiveness.

Evidence for an active handoff between cerebral hemispheres during target tracking

The paper investigates how cerebral hemispheres coordinate during target tracking, finding that alpha and theta power changes signal an active handoff of attention between hemispheres.

Quantifying Differences in Neural Population Activity With Shape Metrics

The paper introduces a framework for comparing neural population activity using shape distances, demonstrating its application across species and behavioral tasks.

Propofol anesthesia destabilizes neural dynamics across cortex

This study uses DeLASE to show that propofol anesthesia reduces dynamic stability in macaque cortex, mirroring destabilized linear systems.

Biomimetic model of corticostriatal micro-assemblies discovers new neural code

The paper introduces a biomimetic model that generates simulated neural activity and cognitive phenomena, validated against experimental data, and discovers a new neural code predicting erroneous behaviors.

Propofol Mediated Unconsciousness Disrupts Progression of Sensory Signals through the Cortical Hierarchy

This study shows propofol disrupts sensory signal progression through the cortical hierarchy by affecting both Up and Down states, with persistent responses only in auditory cortex.

Coding of time with non-linear mixed selectivity in Prefrontal Cortex ensembles

The paper investigates how prefrontal cortex neurons encode time during working memory tasks and finds that non-linear mixed selectivity allows for the maintenance of timing information for the most recent stimulus.

Robust and Brain-Like Working Memory through Short-Term Synaptic Plasticity

This study shows that short-term synaptic plasticity (STSP) improves the robustness and brain-like behavior of artificial recurrent neural networks in working memory tasks.

Reduced variability of bursting activity during working memory

The paper analyzes spiking and LFP data from monkey prefrontal cortex to show task-related reductions in spike variability can co-exist with intermittent spiking.

Traveling waves in the prefrontal cortex during working memory

The paper shows that prefrontal cortex oscillations form traveling waves in theta, alpha, and beta bands, which change during working memory tasks.

Propofol anesthesia alters cortical traveling waves

This study examines how propofol anesthesia affects cortical traveling waves in non-human primates, finding increased slow-delta waves and decreased higher-frequency waves during loss of consciousness.

Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation

This study investigates how propofol induces unconsciousness in non-human primates and how thalamic stimulation reverses its effects by altering neural activity patterns.

Interhemispheric transfer of working memories

The paper shows that visual working memory is transferred between hemispheres through neural activity changes and increased synchrony during a saccade.

Spatial computing for the control of working memory

The paper proposes spatial computing as a mechanism for WM control, finding low-dimensional spatial activity that encodes control-related information in prefrontal cortex.

Conjunctive representation of what and when in monkey hippocampus and lateral prefrontal cortex during an associative memory task

The paper shows that both hippocampus and prefrontal cortex in monkeys maintain a temporal record of events during an associative memory task.

Task-evoked activity quenches neural correlations and variability across cortical areas

The paper shows that task states reduce neural correlations and variability across cortical areas in both primate and human data, increasing information coding capacity.

A geometric characterization of population coding in the prefrontal cortex and hippocampus during a paired-associate learning task

This study characterizes population coding in monkey prefrontal cortex and hippocampus during learning using a new metric called normalized distance.