Author

Rafaella Mergener

University Medical Center GroningenORCID 0000-0002-7814-2936Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

David Coit· 1 shared Emma GerritsiD· 1 shared Gabriel Vasata FurtadoiD· 1 shared Harm H. KampingaiD· 1 shared Hein SchepersiD· 1 shared John LaCavaiD· 1 shared Joris CJ van der LiendeniD· 1 shared Lara BarazzuoliD· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

David Coit

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1 paper

Recent·Most cited

Molecular BiologyeLifePeer-reviewedJan 11, 2022

Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

Wouter Huiting, Suzanne L. Dekker, Joris CJ van der Lienden…·Steven Bergink

The paper shows that targeting ATM, ATR, or DNA topoisomerases causes widespread protein aggregation through chaperone system overload, similar to proteotoxic stress and proteinopathies.

19 citations

humanproteomics

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