Yi Sun

The paper introduces VLP-Open HLA nanoparticles for high-throughput T cell screening, enabling efficient peptide exchange and antigen-specific T cell activation.

This paper designs antibodies de novo with atomic precision using RFdiffusion and yeast display, validated by cryo-EM and biophysical methods.

The paper determines the cryo-EM structure of an MHC-I/TAPBPR peptide intermediate, revealing how antigen proofreading occurs through transient peptide interactions.