Apala Chaudhuri

This paper identifies specific interfacial residues in IGPS that modulate allosteric regulation through structural and dynamic changes induced by targeted mutations.

This paper designs soluble, miniaturized MHC proteins that enable stable expression in E. coli and retain peptide and TCR binding specificity.

The paper determines the cryo-EM structure of an MHC-I/TAPBPR peptide intermediate, revealing how antigen proofreading occurs through transient peptide interactions.