Gulab S Zode

The paper creates a multi-omics atlas of human trabecular meshwork and ciliary body cells, identifying cell types and regulatory programs linked to glaucoma.

This study identifies MIF-CD74 signaling as a regulator of trabecular meshwork dysfunction in glaucoma, showing its role in suppressing Blimp-1 and promoting ECM remodeling and cytoskeletal changes.

The paper shows that impaired mitophagy in retinal ganglion cells contributes to glaucomatous neurodegeneration and that pharmacological or genetic correction can rescue this damage.

This study develops a novel Cre-inducible mouse model of myocilin glaucoma that replicates key human disease features, showing impaired axonal transport precedes retinal ganglion cell loss.

This study shows GLIS1 regulates trabecular meshwork function and intraocular pressure, with a human variant linked to glaucoma.