Author

Franziska Guenther

University of OxfordORCID 0000-0002-7920-7877Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Benedikt Mathias KessleriD· 2 shared Emma J. MurphyiD· 2 shared Hannah B. L. JonesiD· 2 shared Iolanda VendrelliD· 2 shared John B. Davis· 2 shared Katherine S. EnglandiD· 2 shared A. P. TurnbulliD· 1 shared Adán Pinto-FernándeziD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Benedikt Mathias KesslerORCID

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2 papers

Recent·Most cited

USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanisms

Matthew G Williamson, Rachel Heon‐Roberts, Sarah N. J. Franks, Elliot D. Mock, Hannah B. L. Jones, Elena Britti, Ana Belén Malpartida, Mahmoud Adel Bassal, Martha Lavelle, Jack P. Connor, Aina Mogas Barcons, Katherine L. Hammond, Katrina Savory, Pavandeep Rai, Anna Lavayssiere, , Brent James Ryan

This study shows USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanisms, enhancing mitophagy and mitochondrial efficiency in neurons.

bioRxiv · Feb 3, 2025 · PreprintNeuroscience

Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor

Darragh Patrick O'Brien, Hannah B. L. Jones, Yuqi Shi, Franziska Guenther, Iolanda Vendrell, Rosa Viner, Paul E. Brennan, Emma Mead, Tryfon Zarganes‐Tzitzikas, John B. Davis, Adán Pinto-Fernández, Katherine S. England, Emma J. Murphy, A. P. Turnbull, Benedikt Mathias Kessler

This study investigates the structural dynamics of USP30 inhibition by a covalent inhibitor, revealing its binding mechanism and selectivity advantages over non-covalent inhibitors.

Journal of Proteome Research · Jan 13, 2025Peer-reviewedBiochemistry