Author

John B. Davis

University of Oxford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Genetics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:eQTL / molecular QTL mapping· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Paul E. BrennaniD· 3 shared Benedikt Mathias KessleriD· 2 shared Emma J. MurphyiD· 2 shared Emma MeadiD· 2 shared Franziska GuentheriD· 2 shared Hannah B. L. JonesiD· 2 shared Iolanda VendrelliD· 2 shared Katherine S. EnglandiD· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Paul E. BrennanORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanisms

Matthew G Williamson, Rachel Heon‐Roberts, Sarah N. J. Franks, Elliot D. Mock, Hannah B. L. Jones, Elena Britti, Ana Belén Malpartida, Mahmoud Adel Bassal, Martha Lavelle, Jack P. Connor, Aina Mogas Barcons, Katherine L. Hammond, Katrina Savory, Pavandeep Rai, Anna Lavayssiere, , Brent James Ryan

This study shows USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanisms, enhancing mitophagy and mitochondrial efficiency in neurons.

bioRxiv · Feb 3, 2025 · PreprintNeuroscience

Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor

Darragh Patrick O'Brien, Hannah B. L. Jones, Yuqi Shi, Franziska Guenther, Iolanda Vendrell, Rosa Viner, Paul E. Brennan, Emma Mead, Tryfon Zarganes‐Tzitzikas, John B. Davis, Adán Pinto-Fernández, Katherine S. England, Emma J. Murphy, A. P. Turnbull, Benedikt Mathias Kessler

This study investigates the structural dynamics of USP30 inhibition by a covalent inhibitor, revealing its binding mechanism and selectivity advantages over non-covalent inhibitors.

Journal of Proteome Research · Jan 13, 2025Peer-reviewedBiochemistry

Selection and structural characterisation of anti-TREM2 scFvs that reduce levels of shed ectodomain

Aleksandra Szykowska, Yu Chen, Thomas B. Smith, Charlotta Preger, Jingjing Yang, Dongming Qian, Shubhashish M. M. Mukhopadhyay, Edvard Wigren, Stephen J. Neame, S. Gräslund, Helena Persson, Peter J. Atkinson, Elena Di Daniel, Emma Mead, John C. K. Wang, , Alex N. Bullock

The paper identifies and characterizes anti-TREM2 scFv antibodies that inhibit soluble TREM2 production.

Structure · Jul 6, 2021Peer-reviewedMolecular Biology

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

Solveig K. Sieberts, Thanneer Malai Perumal, Minerva M. Carrasquillo, Mariet Allen, Joseph S. Reddy, Gabriel E. Hoffman, Kristen K. Dang, John N. Calley, Philip J. Ebert, James A. Eddy, Xue Wang, Anna K. Greenwood, Sara Mostafavi, Schahram Akbarian, Jaroslav M. Bendl, , Chris Gaiteri

This paper performs a large-scale eQTL meta-analysis across cerebral cortical and cerebellar brain regions, identifying distinct eQTL patterns and demonstrating improved power over existing studies.

Scientific Data · Oct 12, 2020Peer-reviewedGenetics

TargetDB: A target information aggregation tool and tractability predictor

Stéphane De Cesco, John B. Davis, Paul E. Brennan

TargetDB aggregates public target information and predicts tractability to aid in drug target identification.

PLoS ONE · Sep 2, 2020Peer-reviewedBioinformatics