Author

Jeremy D. O’Connell

Harvard UniversityORCID 0000-0002-7861-1122Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Steven P. GygiiD· 2 shared Binkai ChiiD· 1 shared Christina L. ParaggioiD· 1 shared Claudia E. Leonard· 1 shared Devin K. SchweppeiD· 1 shared Jiaming LiiD· 1 shared Jiuchun ZhangiD· 1 shared Jordan A. Coady· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Steven P. GygiORCID

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2 papers

Recent·Most cited

Three ALS genes regulate expression of the MHC class II antigen presentation pathway

Binkai Chi, Muhammet M. Öztürk, Christina L. Paraggio, Claudia E. Leonard, Maria E. Sanita, Mahtab Dastpak, Jeremy D. O’Connell, Jordan A. Coady, Jiuchun Zhang, Steven P. Gygi, Rodrigo Lopez-Gonzalez, Robin Reed

The paper shows that ALS genes FUS, TAF15, and MATR3 regulate the MHC II antigen presentation pathway by downregulating HLA-DR and CD74 through loss of CIITA, with implications for immune system failure in ALS.

bioRxiv · May 11, 2022 · PreprintMolecular Biology

Improved Monoisotopic Mass Estimation for Deeper Proteome Coverage

Ramin Rad, Jiaming Li, Julian Mintseris, Jeremy D. O’Connell, Steven P. Gygi, Devin K. Schweppe

The paper introduces Monocle, an algorithm that improves monoisotopic mass estimation in proteomics, increasing peptide identifications by up to two-fold.

Journal of Proteome Research · Nov 16, 2020Peer-reviewedBioinformatics