Author

Michael Karl Melzer

University Hospital UlmORCID 0000-0002-7902-590XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:multiome· 1

Frequent Co-Authors

Albrecht StenzingeriD· 1 shared Alexander KlegeriD· 1 shared Alica K. Beutel· 1 shared Alireza AbaeiiD· 1 shared Anna HärleiD· 1 shared Anna‐Lena VolckmariD· 1 shared Austin SilvaiD· 1 shared Benjamin Karem NaggayiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Albrecht StenzingerORCID

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1 paper

Recent·Most cited

Exploiting TGF-β-mediated Stromal Programming in Homologous Recombination-Deficient Pancreatic Cancer

Élodie Roger, Hannah M Mummey, Eleni Zimmer, Dharini Srinivasan, Anna Härle, Loïc Moubri, Alica K. Beutel, Rima Singh, Menar Ekizce, Michael Karl Melzer, Yun Jung Lee, Austin Silva, Luisa Härle, Thomas Engleitner, Frank Arnold, , Alexander Kleger

This study shows that ATM-deficient pancreatic cancers reprogram the tumor microenvironment via TGF-β-driven myCAF enrichment, and targeting this stromal axis with chemotherapy improves therapeutic efficacy.

bioRxiv · Sep 16, 2025 · PreprintCancer Biology