Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination
Jordan J. Clark, Irene Hoxie, Daniel C. Adelsberg, Iden A. Sapse, Robert Andreata‐Santos, Jeremy S. Yong, Fatima Amanat, Johnstone Tcheou, Ariel J. Raskin, Gagandeep Singh, Irene González‐Domínguez, Julia E. Edgar, Stylianos Bournazos, Weina Sun, Juan Manuel Carreño, , Florian Krammer
This study identifies non-neutralizing antibodies from vaccinated individuals that protect against SARS-CoV-2 in animal models, highlighting their role through Fc-mediated effector functions and conserved epitope binding.
Cell Reports · Nov 1, 2024Peer-reviewedImmunology