Author

Gitalee Sarker

University of OxfordORCID 0000-0002-2175-8705Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Ana Isabel DomingosiD· 3 shared Davi Sidarta-OliveiraiD· 3 shared Yitao ZhuiD· 3 shared Lu Yao· 2 shared Noelia Martínez‐SáncheziD· 2 shared Samson W. CheungiD· 2 shared Sofia Hult LundhiD· 2 shared Alessandro CiccarelliiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersPhysiology

Ana Isabel DomingosORCID

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3 papers

Recent·Most cited

The perineurium integrates leptin with its sympathetic outflow to protect against obesity

Gitalee Sarker, Emma Rose Haberman, Anandhakumar Chandran, Thomas Monfeuga, Cyrielle Maroteau, Sofia Hult Lundh, Davi Sidarta-Oliveira, Andrea Raimondi, Karin A. Ziegler, Tiago Gomes, Tiago N. Cordeiro, Karishma Parekh, Emilia Schmid, Paola Fernández-Sanmartín, Alina Griebel, , Ana Isabel Domingos

This study identifies perineurial cells as integrators of leptin and sympathetic outflow, showing their role in obesity protection through barrier function and beta 2 adrenergic receptor regulation.

Nature Metabolism · Jul 13, 2026Peer-reviewedNeuroscience

β2AR Agonists Sustain Thermogenesis and Leanness via Sympathofacilitation

Samson W. Cheung, Davi Sidarta-Oliveira, Lu Yao, Yitao Zhu, Gitalee Sarker, Sofia Hult Lundh, Donald A. Morgan, Ji Qu, Sian L. Wilcox, Vladyslav V. Vyazovskiy, David J. Paterson, Dan Li, Kamal Rahmouni, Ana Isabel Domingos

This study shows that β2AR agonists enhance thermogenesis and prevent obesity by improving sympathetic neuron function in mice.

bioRxiv · Jun 13, 2025 · PreprintPhysiology

Sympathetic neuron-derived NPY protects from obesity by sustaining the mural progenitors of thermogenic adipocytes.

Yitao Zhu, Lu Yao, Ana Luisa Gallo-Ferraz, Bruna Bombassaro, Marcela Reymond Simoes, Ichitaro Abe, Jing Wen Chen, Gitalee Sarker, Alessandro Ciccarelli, Linna Zhou, Carl Lee, Davi Sidarta-Oliveira, Noelia Martínez‐Sánchez, Michael Loran Dustin, Cheng Zhan, , Ana Isabel Domingos

This study shows that sympathetic neuron-derived NPY sustains mural progenitors of thermogenic adipocytes, protecting against obesity by maintaining thermogenic capacity.

Nature · Aug 28, 2024Peer-reviewedPhysiology