Sofia Hult Lundh

The perineurium integrates leptin with its sympathetic outflow to protect against obesity

This study identifies perineurial cells as integrators of leptin and sympathetic outflow, showing their role in obesity protection through barrier function and beta 2 adrenergic receptor regulation.

β2AR Agonists Sustain Thermogenesis and Leanness via Sympathofacilitation

This study shows that β2AR agonists enhance thermogenesis and prevent obesity by improving sympathetic neuron function in mice.

A Cross-Species Atlas of the Dorsal Vagal Complex Reveals Neural Mediators of Cagrilintide's Effects on Energy Balance

The paper creates a cross-species atlas of the dorsal vagal complex using single-nucleus RNA sequencing and spatial profiling, revealing molecular mechanisms of cagrilintide's effects on energy balance.

Thermally-induced neuronal plasticity that mediates heat tolerance

The paper identifies hypothalamic preoptic neurons that develop warm-sensitive activity during heat acclimation, enabling heat tolerance through cell-autonomous mechanisms.

Human HYPOMAP: A comprehensive spatio-cellular map of the human hypothalamus

The paper presents HYPOMAP, a comprehensive spatio-cellular map of the human hypothalamus, identifying BMI-associated genes and potential druggable targets.

Microarray profiling of hypothalamic gene expression changes in Huntington's disease mouse models

The paper uses microarray analysis to identify gene expression changes in Huntington's disease mouse models, finding differential expression and pathway dysregulation associated with wild-type and mutant HTT overexpression.