This paper introduces ceSAR, a method combining docking and transcriptional signature connectivity to improve drug discovery and repurposing by reducing false positives and computational costs.

Science Advances · Aug 30, 2024Peer-reviewedBioinformatics

A multilayered post-GWAS analysis pipeline defines functional variants and target genes for systemic lupus erythematosus (SLE)

Mehdi Fazel‐Najafabadi, Loren L. Looger, Harikrishna Reddy Rallabandi, Swapan K. Nath

This paper presents a post-GWAS analysis pipeline to identify functional variants and target genes for SLE using integrative genomic and epigenomic data.

Arthritis & Rheumatology · Feb 19, 2024Peer-reviewedGenetic & Genomic Medicine

A Non-Coding Variant in SLC15A4 Modulates Enhancer Activity and Lysosomal Deacidification Linked to Lupus Susceptibility

Manish Kumar Singh, Guru Prashad Maiti, Harikrishna Reddy Rallabandi, Mehdi Fazel‐Najafabadi, Loren L. Looger, Swapan K. Nath

Frontiers in Lupus · Nov 22, 2023Peer-reviewedGenetics

Connecting omics signatures of diseases, drugs, and mechanisms of actions with iLINCS

Marcin Pilarczyk, Mehdi Fazel‐Najafabadi, Michal Kouril, Behrouz Shamsaei, Juozas Vasiliauskas, Wen Niu, Naim Al Mahi, Lixia Zhang, Nicholas A. Clark, Yan Ren, Shana White, Rashid Saadman Karim, Huan Xu, Jacek Biesiada, Mark F. Bennett, , Mario Medvedovic

iLINCS provides a web-based platform for analyzing omics signatures of diseases and cellular perturbations through integrative analytics and visualization tools.

Nature Communications · Aug 9, 2022Peer-reviewedBioinformatics