James K. Reigle

Accelerating Drug Discovery and Repurposingby Combining Transcriptional Signature Connectivity with Docking

This paper introduces ceSAR, a method combining docking and transcriptional signature connectivity to improve drug discovery and repurposing by reducing false positives and computational costs.

Molecular Neurobiology of Loss

This study investigates the molecular mechanisms of psychological loss in rats using a multi-omics approach, finding changes in microglia and extracellular matrix linked to impaired emotional processing.

Pharmacological impacts on schizophrenia functional analysis: a postmortem proteome study.

This study analyzes the proteomic changes in schizophrenia using postmortem brain samples and shows how antipsychotic drugs modulate these changes across multiple biological levels.

Persistence: Using Protein Turnover to Expand the Applications of Transcriptomics

The paper introduces 'persistence' as a metric combining protein turnover and RNA expression to improve functional insights from transcriptomics data, showing its effectiveness in schizophrenia datasets.

Region-Specific PSD-95 Interactomes Contribute to Functional Diversity of Excitatory Synapses in Human Brain.

This study identifies region-specific PSD-95 interactomes in human brain regions and links them to potential drug targets using bioinformatics and perturbagen databases.

Transcriptional profile of pyramidal neurons in chronic schizophrenia reveals lamina-specific dysfunction of neuronal immunity

The paper identifies lamina-specific gene expression changes in pyramidal neurons from schizophrenia patients compared to controls, highlighting immune and synaptic pathway disruptions.

Integrative Omics for Informed Drug Repurposing: Targeting CNS Disorders

This paper reviews signature-based in silico approaches for drug repurposing in CNS disorders, integrating data science platforms to improve clinical relevance and address regulatory and knowledge challenges.