Author

Chris Bristow

The University of Texas MD Anderson Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Alejandro Hernandez Martinez· 1 shared Alexey V. SorokiniD· 1 shared Amanda AndersoniD· 1 shared Andrea VialeiD· 1 shared Angela K. DeemiD· 1 shared Annette A. MachadoiD· 1 shared Chi Wut WongiD· 1 shared Chieh-Yuan LiiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

Alejandro Hernandez Martinez

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2 papers

Recent·Most cited

Adaptive Plasticity Tumor Cells Modulate MAPK-Targeting Therapy Response in Colorectal Cancer

Oscar Eduardo. Villarreal, Yixin Xu, Ha Tran, Annette A. Machado, Dionne Prescod, Amanda Anderson, Rosalba Minelli, Mike Peoples, Alejandro Hernandez Martinez, Hey Min Lee, Chi Wut Wong, Natalie Wall Fowlkes, Preeti Kanikarla Marie, Alexey V. Sorokin, Jumanah Yousef Alshenaifi, , Scott Kopetz

The paper identifies adaptive plasticity tumor (APT) cells that reduce response to MAPK inhibitors in colorectal cancer by increasing stemness and ASCL2 expression, and shows that targeting APT cells improves therapy efficacy.

bioRxiv · Jan 22, 2025 · PreprintCancer Biology

Multiplexed pooled library screening with Cpf1

Jintan Liu, Sanjana Srinivasan, Chieh-Yuan Li, I-Lin Ho, Johnathon Lynn Rose, MennatAllah Shaheen, Gang Wang, Wantong Yao, Angela K. Deem, Chris Bristow, Traver Hart, Giulio Francesco Draetta

The paper develops a multiplexed CRISPR/Cas9-based screening strategy using AsCpf1 to create a smaller, more efficient genome-wide knockout library.

Nature Communications · Jul 17, 2019Peer-reviewedSystems Biology