Targeting Circulating FABP4 Ameliorates Obesity-Associated Hepatic Steatosis
Xingshan Jiang, Anthony M. Avellino, Jianyu Yu, Shanshan Liu, Zhaohua Wang, Xiaochun Han, Himani Thakkar, Jonathan S. Shilyansky, Zhen Xu, Nicholas Schnicker, Bhagirath Chaurasia, Jiaqing Hao, Sonia L. Sugg, Bing Li
This study identifies circulating FABP4 as a mediator of adipocyte-hepatocyte lipid crosstalk in obesity and shows that targeting it with a monoclonal antibody reduces hepatic steatosis in mouse models.
bioRxiv · Jan 26, 2026 · PreprintPathology