Nicholas Schnicker

The paper identifies monoclonal C3- and C5-nephritic factors, reveals their structural interactions with convertases, and explains their dual role in activating or inhibiting convertase activity.

This study identifies circulating FABP4 as a mediator of adipocyte-hepatocyte lipid crosstalk in obesity and shows that targeting it with a monoclonal antibody reduces hepatic steatosis in mouse models.

This study shows CpoS forms tetramers that mediate Inc-Inc interactions and Rab GTPase engagement, facilitating vesicle trafficking during Chlamydia trachomatis infection.

The paper examines how divergence in intrinsically disordered regions of a eukaryotic transcription factor affects its co-TF dependence across species.

This study determines the structural and kinetic mechanism of DNA Polymerase β processing 1-nt gaps in the nucleosome during DNA repair.

This study reveals the conformational landscape of soluble α-klotho using cryo-EM, showing flexibility and multiple forms that support its FGFR-independent functions.

The paper reports the cryo-EM structure of a single domain antibody bound to FAP, revealing a unique epitope and describing affinity improvements through CDR3 mutations.

The paper shows Mitoregulin self-associates into hexameric pore-like structures through co-immunoprecipitation, modeling, and gel analysis.

This study investigates the structure and function of the Fatty Acid Kinase complex in Staphylococcus aureus using modeling, biochemical, and cell-based approaches, revealing key residues and interactions essential for its activity.

This paper develops humanized anti-FABP4 monoclonal antibodies that inhibit breast cancer tumor growth and metastasis by targeting FABP4's role in lipid metabolism.