Zhen Xu

The paper identifies monoclonal C3- and C5-nephritic factors, reveals their structural interactions with convertases, and explains their dual role in activating or inhibiting convertase activity.

This study identifies circulating FABP4 as a mediator of adipocyte-hepatocyte lipid crosstalk in obesity and shows that targeting it with a monoclonal antibody reduces hepatic steatosis in mouse models.

This study shows CpoS forms tetramers that mediate Inc-Inc interactions and Rab GTPase engagement, facilitating vesicle trafficking during Chlamydia trachomatis infection.

This study determines the structural and kinetic mechanism of DNA Polymerase β processing 1-nt gaps in the nucleosome during DNA repair.

This study reveals the conformational landscape of soluble α-klotho using cryo-EM, showing flexibility and multiple forms that support its FGFR-independent functions.

The paper reports the cryo-EM structure of a single domain antibody bound to FAP, revealing a unique epitope and describing affinity improvements through CDR3 mutations.

The paper shows Mitoregulin self-associates into hexameric pore-like structures through co-immunoprecipitation, modeling, and gel analysis.

This study investigates the structure and function of the Fatty Acid Kinase complex in Staphylococcus aureus using modeling, biochemical, and cell-based approaches, revealing key residues and interactions essential for its activity.

This paper develops humanized anti-FABP4 monoclonal antibodies that inhibit breast cancer tumor growth and metastasis by targeting FABP4's role in lipid metabolism.

The paper identifies differences in the tau interactome between fetal and Alzheimer disease brains, showing isoform-dependent interactions with 14-3-3 proteins.