Xu Zhang

This paper introduces an AI-assisted native proteomics method to identify protein conformations pre- and post-assembly, validated on ribosomal proteins and drug interactions.

The paper identifies master regulator dependencies in coexisting diffuse midline glioma subpopulations and shows that combination therapy targeting these regulators improves survival in vivo.

The paper shows that ribosome assembly stress triggers a pathway that balances Hsf1 and Ifh1 activity to prevent proteotoxic stress in yeast.