Pharmacology & ToxicologybioRxivPreprint
Transient silencing of spinal nociceptive neurons leads to a long-term reduction in joint pain mediated by recruitment of opioid activity.
Silvia Silva-Hucha, Charlotte Leese, Sara Hestehave…·Maria Maiarù
The paper shows that SP-BOT induces two phases of pain relief in inflammatory arthritis, with long-term effects mediated by endogenous opioids.
DOI 10.64898/2026.01.14.699276