Sandrine M. Géranton

This study shows that pre-injury stress in male mice reduces pain symptoms in osteoarthritis, while increasing them in females, revealing sex-specific effects of stress on pain resilience.

This study examines the effects of voluntary wheel running on pain and gait in mice with osteoarthritis, finding both pain relief and temporary gait worsening.

The paper shows that SP-BOT induces two phases of pain relief in inflammatory arthritis, with long-term effects mediated by endogenous opioids.

This study shows that inhibiting FKBP51 early in joint pain reduces both sensory and emotional symptoms for up to 6 months, while late inhibition only provides temporary relief.

This study shows that sub-chronic stress causes hypomethylation of the Fkbp5 promoter, increasing chronic pain vulnerability, but reversing this methylation does not prevent pain.

The paper examines transcriptional changes across tissues and time after traumatic stress exposure in rats to identify intervention windows for preventing adverse neuropsychiatric outcomes.

The paper shows that early functional measures in joint disease models predict long-term sensory and emotional symptoms, suggesting their use in clinical settings for better pain management and prevention of emotional comorbidities.

The paper investigates the DNA methylation profile of FKBP5 in chronic pain models, finding significant differences between pain states and correlations between CNS and blood methylation, suggesting FKBP5 as a potential biomarker for chronic pain diagnosis and vulnerability prediction.