Sara Hestehave

This study demonstrates that vertical climbing in mice is a reliable and translationally relevant measure of pain-related functional impairment across multiple pain models.

This study evaluates home-cage activity metrics for detecting postprocedural pain in a plantar incision mouse model and finds they cannot reliably distinguish pain-related changes.

This study identifies peripheral nociceptor hyperexcitability as a mechanism underlying pain in DM1 using a mouse model.

This study shows that neonatal surgical injury changes adult social behavior and cortical network responses to subsequent injury in rats.

This study shows that pre-injury stress in male mice reduces pain symptoms in osteoarthritis, while increasing them in females, revealing sex-specific effects of stress on pain resilience.

This study examines the effects of voluntary wheel running on pain and gait in mice with osteoarthritis, finding both pain relief and temporary gait worsening.

The paper shows that SP-BOT induces two phases of pain relief in inflammatory arthritis, with long-term effects mediated by endogenous opioids.

This study refines the adjuvant-induced rat monoarthritis model by optimizing injection volume and site, finding that lower volumes reduce inflammation spread without compromising model validity.

This study shows that inhibiting FKBP51 early in joint pain reduces both sensory and emotional symptoms for up to 6 months, while late inhibition only provides temporary relief.

This study shows that sub-chronic stress causes hypomethylation of the Fkbp5 promoter, increasing chronic pain vulnerability, but reversing this methylation does not prevent pain.

This study shows that CBD3063, a CRMP2 modulator, reduces OA pain in rodents by decreasing CaV2.2 membrane expression and neural activity.

The paper shows that early functional measures in joint disease models predict long-term sensory and emotional symptoms, suggesting their use in clinical settings for better pain management and prevention of emotional comorbidities.