Neal K. Devaraj

This paper develops a method to attach proteins to liposomes via N-terminal alkylation using TA4C, enabling targeted delivery to EGFR-overexpressing cells.

This study demonstrates a reaction-driven process that converts RNA-rich condensates into lipid vesicles, selectively concentrating RNA and enabling catalytic activity.

This study investigates how 1-deoxysphingolipids affect membrane properties and cargo trafficking in the early secretory pathway by analyzing their subcellular distribution and effects on ER membrane fluidity and ERES.

This paper introduces FACES, a tool for imaging lipid pools and transbilayer orientation in living cells, and applies it to study lipid transfer proteins and membrane asymmetry.

This study demonstrates the de novo formation of lipid bilayers from primitive metabolites without preexisting membranes or templates.

This paper describes a system for displaying peptides on artificial cell membranes using engineered pore-forming proteins, enabling the assembly of artificial tissue-like structures with signal transduction capabilities.

This study shows that E. coli TGT can modify DNA substrates, developing a DNA-TAG system for site-specific labeling of DNA.

This study shows DNA can functionalize lipid sponge droplets, with size-dependent partitioning and applications for cargo control and signaling.

The paper demonstrates a method to synthesize membrane-bound vesicles using a cell-free system by coupling fatty acyl-CoA ligase expression with lipid precursors.

This paper describes a chemoenzymatic method using bacterial fatty acid synthase to generate phospholipid membranes from acetyl-CoA and malonyl-CoA precursors.

This paper demonstrates the heterologous expression of methylxanthine synthesis enzymes in human cells and their use as inducible reporter proteins for cell-cell communication.

This paper introduces lipid sponge droplets as programmable synthetic organelles that can sequester proteins, enhance reaction rates, and control enzymatic reactions through reversible and optically controlled interactions.

This study converts astrocytes into functional neurons to reverse Parkinson's disease in mice by suppressing PTB, restoring dopamine levels and nigrostriatal pathways.

This study presents artificial cell-mimics capable of communication and quorum sensing through diffusive protein signals, enabling task distribution and differentiation in tissue-like arrangements.