Roberto J. Brea

This study investigates how 1-deoxysphingolipids affect membrane properties and cargo trafficking in the early secretory pathway by analyzing their subcellular distribution and effects on ER membrane fluidity and ERES.

This paper introduces FACES, a tool for imaging lipid pools and transbilayer orientation in living cells, and applies it to study lipid transfer proteins and membrane asymmetry.

The paper demonstrates a method to synthesize membrane-bound vesicles using a cell-free system by coupling fatty acyl-CoA ligase expression with lipid precursors.

This paper describes a chemoenzymatic method using bacterial fatty acid synthase to generate phospholipid membranes from acetyl-CoA and malonyl-CoA precursors.

This paper introduces lipid sponge droplets as programmable synthetic organelles that can sequester proteins, enhance reaction rates, and control enzymatic reactions through reversible and optically controlled interactions.