Induction of core symptoms of autism spectrum disorders by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys
Shihao Wu, Xiao Li, Dongdong Qin, Lin-Heng Zhang, Tian‐Lin Cheng, Zhifang Chen, Binbin Nie, Xiaofeng Ren, Jing Wu, Wenchao Wang, Yingzhou Hu, Yilin Gu, Longbao Lv, Yong Yin, Xintian Hu, Zilong Qiu
This study uses in vivo CRISPR/Cas9 to edit MECP2 in adolescent rhesus monkeys, resulting in autistic-like behaviors.
中国科学通报：英文版 · Dec 17, 2020Peer-reviewedNeuroscience